Aβ Imaging in Aging, Alzheimer’s Disease, and Other Neurodegenerative Conditions

Abstract

In vivo imaging of β-amyloid (Αβ) has transformed the assessment of Αβ pathology and its changes over time, extending our insight into Aβ deposition in the brain by providing highly accurate, reliable, and reproducible quantitative statements of regional or global Aβ burden in the brain, proving essential in anti-Αβ therapeutic trials. Although cross-sectional evaluation of Αβ burden does not strongly correlate with cognitive impairment in AD, it does correlate with memory impairment and a higher risk for cognitive decline in the aging population and MCI subjects. This correlation with memory impairment, one of the earliest symptoms of AD, suggests that Αβ deposition is not part of normal ag..